Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes

Lee, Do Hee; Lee, Youra; Ryu, Joohyun; Park, Sung Goo; Cho, Sayeon; Lee, Je-Jung; Choi, Chan; Park, Byoung Chul

doi:10.1007/s10059-011-1053-z

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Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes

Lee, Do Hee;
Lee, Youra;
Ryu, Joohyun;
Park, Sung Goo;
Cho, Sayeon;
외 3명

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10

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10

초록

In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.

키워드

AAT; AGR2; DBP; gastric cancer; metastasis; proteome; 2-DIMENSIONAL GEL-ELECTROPHORESIS; PLASMINOGEN-ACTIVATOR EXPRESSION; MASS-SPECTROMETRY; BREAST-CANCER; ESTROGEN-RECEPTOR; TUMOR PROGRESSION; HUMAN HOMOLOG; GENE XAG-2; MECHANISMS; GROWTH

제목: Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes

저자: Lee, Do Hee; Lee, Youra; Ryu, Joohyun; Park, Sung Goo; Cho, Sayeon; Lee, Je-Jung; Choi, Chan; Park, Byoung Chul

DOI: 10.1007/s10059-011-1053-z

발행일: 2011-06

유형: Article

저널명: Molecules and Cells

권: 31

호: 6

페이지: 563 ~ 571

언어: ENG

출판사: KOREAN SOC MOLECULAR & CELLULAR BIOLOGY

발행국가: 대한민국

분량: 9 페이지

ISSN: E 0219-1032
P 1016-8478