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HC1에 의한 식도염에서 식도와 하부괄약근의 점막과 근육세포의 염증변화
Inflammatory Changes in Esophagus and Lower Esophageal Sphincter of HCl-elicited Esophagitis in Cats
- Lee, Seung June;
- Kim, Chang Jong;
- Sohn, Uy Dong;
- Lee, Moo Yeol;
- Shin, Yong Kyoo;
- 외 1명
초록
The underlying mechanism by which the reflux of gastric juice elicits oesophagitis remains unclear. To investigate inflammatory response to HC1 in tissue of esophagus and lower esophageal sphincter, experimental esophagitis was elicited by perfusion of 0.1 N HC1 in cats. There was no difference in phospholipase A 2 (PLA2) activity of tissue between control and esophagitis. Myeloperoxidase activity in esophagitis was significantly greater than that of control. However, histamine content in esophageal mucosa of esophagitis was significantly smaller than that of control. These findings suggest that inflammatory response to HC1 in esophagitis is related to changes of myeloperoxidase activity and histamine rather than change of PLA2 activity.
키워드
Esophagitis; phospholipase A2; myeloperoxidase; histamine
- 제목
- HC1에 의한 식도염에서 식도와 하부괄약근의 점막과 근육세포의 염증변화
- 제목 (타언어)
- Inflammatory Changes in Esophagus and Lower Esophageal Sphincter of HCl-elicited Esophagitis in Cats
- 저자
- Lee, Seung June; Kim, Chang Jong; Sohn, Uy Dong; Lee, Moo Yeol; Shin, Yong Kyoo; Sim, Sang Soo
- 발행일
- 2002-02
- 저널명
- 약 학 회 지
- 권
- 46
- 호
- 1
- 페이지
- 58 ~ 62
- 언어
- KOR
- 출판사
- 대한약학회
- 발행국가
- 대한민국
- 분량
- 5 페이지
- ISSN
- E 2383-9457
P 0377-9556