바소프레신과 데스모프레신이 가토 음경해면체 평활근의 수축 및 이완에 미치는 영향

초록

Purpose: This study aimed to investigate the effects of vasopressin and desmopressin on the contractile and relaxative responses of rabbit cavernosal smooth muscle. Materials and Methods: Isometric tension studies were conducted to investigate the effects of vasopressin (10-14 -10-8 M) and desmopressin (10-14-10-8 M) on the contraction and relaxation responses of rabbits cavernous muscle strips in an organ bath. The effects of pretreatment with phenylephrine (10-5 M), L-NAME (10-5 M) and indomethacin (10-5M) on the contraction and relaxation responses of the vasopressin and desmopressin were also investigated. The statistics were analyzed by Student's t-test and ANOVA. Results: Vasopressin contracted the strips in a dose-dependent manner, while desmopressin did not. The phenylephrine-induced contraction was dose-dependently increased by vasopressin, but it was dose-dependently relaxed by desmopressin. L-NAME pre-treatment did not block the relaxation response, but indomethacin pre-treatment did. Vasopressin-induced contraction occurred the via V1 receptor, while desmopressin-induced relaxation occurred via the V2 receptor. Conclusions: Vasopressin, in pathophysiological circumstances, would worsen erectile dysfunction. On the contrary, desmopressin, which may induce an endothelium-dependent relaxation of the cavernous smooth muscles, would be good for erectile function.

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