Anterior segment swept-source OCT-based assessment of corneal refractive and thickness profiles in SJS/TEN patients: A controlled comparative study

초록

Purpose : To analyze anterior, posterior, and total corneal refractive profiles and thickness using anterior segment swept-source optical coherence tomography (AS SS-OCT) in Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) patients. Methods : This retrospective study compared 23 eyes from 14 SJS/TEN patients (Group 2) with 23 eyes from 14 age- and sex-matched controls (Group 1). AS SS-OCT measured corneal refractive profiles and pachymetry. Parameters included anterior, posterior, and total corneal power (TCP) values, posterior-to-anterior curvature ratio (P/A ratio), maximal corneal power (Kmax), and thickness profiles. Group 2 was subdivided based on corneal opacity presence (Subgroup A) or absence (Subgroup B). Results : Group 2 showed significantly higher corneal astigmatism and Kmax values for both anterior and posterior curvatures. Steep TCP and total corneal astigmatism were higher in Group 2. The thinnest corneal thickness was lower, and its distance from the corneal vertex was greater in Group 2. Subgroup analysis revealed that these differences were primarily attributed to the presence of corneal opacity. Additionally, automated keratometry of the anterior corneal surface showed significantly higher values, including steep, flat, average K, and corneal astigmatism, in Group 2. Conclusions : AS SS-OCT shows significant alterations in both anterior and posterior corneal curvatures in SJS/TEN patients. These findings emphasize the importance of considering posterior corneal curvature changes in pre-cataract surgery assessments and contact lens prescriptions for SJS/TEN patients.