Regioselective Cobalt-Catalyzed Protoboration of Alkynes

초록

A regioselective cobalt-catalyzed protoboration of alkynes has been developed, utilizing diboron as the borylation source for the efficient synthesis of alkenylborates. The reaction proceeds via cobalt-boryl intermediates, diverging from conventional Co−H chemistry. By fine-tuning the phosphine ligand side chains, we achieved excellent reactivity and regioselectivity across a wide range of internal and terminal alkynes. This Co-catalyzed method offers significant advantages in terms of both efficiency and environmental impact, making it an attractive approach for the synthesis of complex organic molecules. © 2024 Wiley-VCH GmbH.

키워드