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The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells
- An, Joo-Hee;
- Jang, Sang-Min;
- Kim, Jung-Woong;
- Kim, Chul-Hong;
- Song, Peter I.;
- 외 1명
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14Citations
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13초록
The expression of the cell cycle inhibitor p21 is increased in response to various stimuli and stress signals through p53-dependent and independent pathways. We demonstrate in this study that forkhead box A1/2 (FOXA1/2) is a crucial transcription factor in the activation of p21 transcription via direct binding to the p21 promoter in p53-null H1299 lung carcinoma cells. In addition, histone deacetylase inhibitor trichostatin A (TSA)-mediated upregulation of p21 expression was repressed by knockdown of FOXA1/2 in H1299 cells. Consequently, these results suggest that FOXA1/2 is required for p53-independent p21 expression. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
키워드
Transcription factor FOXA1/2; p21; Trichostatin A; Target gene; p53-Independent pathway; HISTONE DEACETYLASE INHIBITORS; HEPATOCYTE NUCLEAR FACTOR-3-BETA; WAF1/CIP1 GENE PROMOTER; LUNG-CANCER; TUMOR-SUPPRESSOR; SP1 SITES; P21(WAF1/CIP1) EXPRESSION; TRANSCRIPTION FACTORS; EPITHELIAL-CELLS; DRUG-RESISTANCE
- 제목
- The expression of p21 is upregulated by forkhead box A1/2 in p53-null H1299 cells
- 저자
- An, Joo-Hee; Jang, Sang-Min; Kim, Jung-Woong; Kim, Chul-Hong; Song, Peter I.; Choi, Kyung-Hee
- 발행일
- 2014-11
- 유형
- Article
- 저널명
- FEBS Letters
- 권
- 588
- 호
- 21
- 페이지
- 4065 ~ 4070
- 언어
- ENG
- 출판사
- ELSEVIER SCIENCE BV
- 발행국가
- 네덜란드
- 분량
- 6 페이지
- ISSN
- E 1873-3468
P 0014-5793