A Facile Access to 4-Substituted-2-naphthols via a Tandem Friedel-Crafts Reaction: A β-Chlorovinyl Ketone Pathway

초록

A one-pot synthesis of 2-naphthol derivatives is accomplished using a tandem Friedel–Crafts reaction sequence. The developed methodology allows for a concomitant construction of up to three C–C bonds between readily available alkynes and phenylacetyl chloride derivatives by an intermolecular Friedel–Crafts acylation of alkynes followed by an intramolecular Friedel–Crafts alkylation of β-chlorovinyl ketone intermediates.

키워드