건강보험청구자료와 의약품정보데이터베이스를 이용한중환자실 약물상호작용 분석

초록

A drug-drug interaction occurs when two or more drugs interact with each other; this can clinically result in adverse drug events with changes in drug effects. This study aimed to analyze prevalence of polypharmacy and potential drug-drug interactions (pDDI) with opioid analgesics in geriatric patients in the intensive care unit using claims data. We used the aged patients’ sample for 2016 and Micromedex as the drug information database in this analysis. Among 1,327,455 patients, we selected 20,050 patients who were prescribed opioids in the intensive care unit. Mean age was 76.4 years and median ICU stay was 3 days. Among the 20,050 patients, prevalence of coprescription was 91.1%; median number of drugs prescribed per patient was 3 (range, 0-25). The prevalence of pDDI between opioids and other drugs was 54.3%. Multiple logistic regression showed that pDDI was related to surgery, number of drugs prescribed, age, and admission through emergency room.

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