Viral Vector System for Production of Pharmaceutical Proteins

초록

Most of pharmaceutical proteins are usually produced by the animal, insect cell and yeast culture. The proteins must be produced in strictly controlled-facilities, which is one of major causes for increasing production cost. So, in spite of increasing demand on the proteins in worldwide, their generalization has been very restrictive. To decrease the production cost, many scientists have been interested in production of pharmaceutical proteins by using the plant system for a long time. The plant system must be alternative production means, for it is easily scalable, more production cost effective, and safer than animal system. For this purpose, several techniques have been developed: stable expression by transformation of nuclear and chloroplast genome and transient expression by viral vectors. Among them, the deconstructed viral vector system has made it possible to produce recombinant proteins massively, rapidly, and transiently. So, the plant viral expression systems might be a suitable platform for production of pharmaceutical proteins in plants. In this review, we will describe the plant viral vector systems and their application.

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