건강증진센터를 내원한 폐경 및 폐경주변기 여성에서 혈청 Ferritin과 대사증후군

초록

Objectives: The purpose of this study was to examine the relationship between serum ferritin and metabolic syndrome in peri- and postmenopausal women. Methods: The study subjects consisted of 2,091 peri- and postmenopausal women who visited the hospital for a health check-up in 2007. They were divided into the metabolic syndrome group (MetS) and the non-metabolic syndrome group (Non-MetS). Results: Mean serum ferritin values were 65.16 ± 33.69 ng/mL in MetS and 57.82 ± 32.51 ng/mL in Non-MetS (P = 0.000). In MetS, serum ferritin had a positive correlation with hemoglobin (Hb), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglyceride, aspartate transaminase (SGOT), alanine transaminase (SGPT), uric acid, and high-sensitivity C-reactive protein (hs-CRP) but a negative correlation with high-density lipoprotein (HDL)-cholesterol and low-density lipoprotein (LDL)-cholesterol (P ＜ 0.05). From multiple linear models, hs-CRP, HDL-cholesterol, SGOT, HOMA-IR, and hemoglobin level were found to be the best predictors of serum ferritin in MetS (R2 = 0.106; P ＜ 0.05). Conclusion: The serum ferritin level in MetS was higher than in Non-MetS in postmenopausal women. In MetS, with increasing hs-CRP, SGOT, HOMA-IR, and hemoglobin levels and decreasing HDL-cholesterol levels, the serum ferritin level seems to increase. (J Korean Soc Menopause 2011;17:166-173)

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