Targeted Precision Cryotherapy With a Poly-D,L-Lactic Acid–Hyaluronic Acid Hybrid Filler for Facial Skin Quality Enhancement: A Controlled Study

초록

Background Targeted precision cryotherapy has emerged as a novel approach in aesthetic dermatology, offering enhanced precision and safety during procedures. This study evaluated the efficacy and safety of a poly-D,L-lactic acid–hyaluronic acid (PDLLA–HA) hybrid filler administered using a TargetCool device to improve facial skin quality. Materials and Methods A prospective controlled study was conducted in 20 Korean women with melasma, hyperpigmentation, or dark spots. One hemiface was treated with PDLLA–HA using a precision cryotherapy device, while the contralateral side received the same formulation via a microneedle roller. Skin parameters, including melanin content, dermal density, pore volume, pore density, pore count, and redness, were assessed at baseline, during treatment, and 1 month after the final session. Visual grading, patient-reported outcomes, and safety evaluations were also performed. Results Cryotherapy-assisted delivery demonstrated significantly greater improvements than microneedling in melanin reduction (31.28% vs. 23.40%), dermal density (30.07% vs. 17.37%), and pore-related parameters, including volume (53.43% vs. 33.61%) and density (57.80% vs. 21.62%). Redness was significantly reduced on the cryotherapy-treated side. Participant satisfaction was high, with consistent improvements in skin texture and overall appearance. No adverse events were observed. Conclusion Precision cryotherapy-assisted delivery of PDLLA + HA provides superior efficacy and favorable safety compared with conventional application methods. This approach may enhance transdermal delivery while minimizing tissue trauma, representing a promising strategy for advanced aesthetic dermatologic treatments.

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