Predicting cumulative incidence of adverse events in older patients with cancer undergoing first-line palliative chemotherapy: Korean Cancer Study Group (KCSG) multicentre prospective study

초록

BACKGROUND: Older patients have increased risk of toxicity from chemotherapy. Current prediction tools do not provide information on cumulative risk. METHODS: Patients aged >= 70 years with solid cancer were prospectively enrolled. A prediction model was developed for adverse events (AEs) >= Grade 3 (G3), based on geriatric assessment (GA), laboratory, and clinical variables. RESULTS: 301 patients were enrolled (median age, 75 years). Median number of chemotherapy cycles was 4. During first-line chemotherapy, 53.8% of patients experienced AEs >= G3. Serum protein < 6.7 g/dL, initial full-dose chemotherapy, psychological stress or acute disease in the past 3 months, water consumption < 3 cups/day, unable to obey a simple command, and self-perception of poor health were significantly related with AEs >= G3. A predicting model with these six variables ranging 0-8 points was selected with the highest discriminatory ability (c-statistic = 0.646), which could classify patients into four risk groups. Predicted cumulative incidence of AEs >= G3 was discriminated according to risk groups. CONCLUSIONS: This prediction tool could identify the risk of AEs >= G3 after chemotherapy and provide information on the cumulative incidence of AEs in each cycle.

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