Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells

Chang, Dong Jo; Jeong, Mi Young; Song, Jiho; Jin, Chang Yun; Suh, Young-Ger; Kim, Hyun-Jung; Min, Kyung Hoon

doi:10.1016/j.bmcl.2011.09.099

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Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells

Chang, Dong Jo;
Jeong, Mi Young;
Song, Jiho;
Jin, Chang Yun;
Suh, Young-Ger;
... Kim, Hyun-Jung;
... Min, Kyung Hoon

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16

초록

1,3,4-Oxadiazole derivatives were found to enhance astrocyte differentiation in rat fetal neural stem cells (NSCs). Differentiation activity was assessed by immunocytochemistry and analysis of mRNA expression of astrocyte markers, GFAP and S100. Compounds 7 and 8 showed approximately a two-fold increase in astrocyte differentiation without engagement of neuronal differentiation and detectable cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

키워드

Neural stem cell; Small molecule; Astrocyte; Differentiation; 1,3,4-Oxadiazole; PROGENITOR CELLS; NEURONAL DIFFERENTIATION; NEUROGENESIS; MAINTENANCE; DISEASE

제목: Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells

저자: Chang, Dong Jo; Jeong, Mi Young; Song, Jiho; Jin, Chang Yun; Suh, Young-Ger; Kim, Hyun-Jung; Min, Kyung Hoon

DOI: 10.1016/j.bmcl.2011.09.099

발행일: 2011-12

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 21

호: 23

페이지: 7050 ~ 7053

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 4 페이지

ISSN: E 1464-3405
P 0960-894X