Effect of structural stiffness of composite bone plate-scaffold assembly on tibial fracture with large fracture gap

초록

In high-energy trauma, severe segmental bone fractures are generally fixed using a combination of a bone plate and a scaffold. In the present study, simulation of the bone healing process of a fractured tibia with a 30 mm fracture gap to which a bone plate-scaffold assembly was applied was performed. A flexible composite bone plate was used to assemble the bone fractures, and a scaffold was inserted in the defected segment. It is well known that the material properties of a bone plate and scaffold affect the healing progress of bone fractures. Therefore, three polymer-based composite materials with different Young's moduli and a few functionally graded materials (FGMs) were used to construct the scaffolds in order to investigate the effect of structural stiffness on the healing process of fractured bones. A mechanoregulation algorithm with a deviatoric strain was programmed in a user subroutine, and iterative calculations were performed using the commercially available finite element code ABAQUS 6.10 to estimate the tissue differentiation process during bone healing. The most appropriate combination of a bone plate and scaffold was proposed for a particular fracture configuration. (C) 2015 Elsevier Ltd. All rights reserved.

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