Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications

Bose, Rajendran J. C.; Lee, Soo-Hong; Park, Hansoo

doi:10.1016/j.jiec.2016.02.015

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Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications

Bose, Rajendran J. C.;
Lee, Soo-Hong;
Park, Hansoo

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WEB OF SCIENCE

27

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SCOPUS

33

초록

Antiproliferative drug (sirolimus or propolis) loaded lipid polymer hybrid nanospheres (LPHNSs) were prepared by single step method. The effects of different lipids on properties of nanocarrier were investigated. Furthermore, anti proliferative efficiency and cytotoxicity of LPHHNSs-propolis or sirolimus were investigated on human aortic smooth muscle cells (HASMCs), and human aortic endothelial primary cells (HAECs) respectively. The characterization of LPHNSs revealed that the lipids used in the formulation influence physiochemical parameters. In vitro studies showed that the encapsulated sirolimus and propolis significantly reduced the proliferation of HASMCs, while maintaining high HAECs viability. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

키워드

Lipid polymer hybrid nanospheres; Antiproliferative drugs; Human aortic smooth muscle cells; Anti proliferation assessment; Cytotoxicity on human aortic endothelial cells; DRUG-DELIVERY PLATFORM; VASCULAR SMOOTH-MUSCLE; ELUTING STENTS; IN-VITRO; CORONARY STENT; NANOPARTICLES; SIROLIMUS; RAPAMYCIN; RESTENOSIS; PREVENTION

제목: Lipid polymer hybrid nanospheres encapsulating antiproliferative agents for stent applications

저자: Bose, Rajendran J. C.; Lee, Soo-Hong; Park, Hansoo

DOI: 10.1016/j.jiec.2016.02.015

발행일: 2016-04

유형: Article

저널명: Journal of Industrial and Engineering Chemistry

권: 36

페이지: 284 ~ 292

언어: ENG

출판사: ELSEVIER SCIENCE INC

발행국가: 미국

분량: 9 페이지

ISSN: E 1876-794X
P 1226-086X