체중감량 목적으로 사용되는 녹차추출물의 임상정보

초록

Background: Green tea extracts are approved as nonprescription drug and available as health functional foods, health foods, andbeverages. Clinical information on the products is lacking. Methods: Information about the products on green tea nonprescriptiondrugs was obtained from the website of the Korea Pharmaceutical Information Center. The Naver, i.e., a top ranking online searchportal, was used for compiling the list of the health functional food products using key words of 'green tea catechin' on August 23,2018. The recommended daily dosages of catechins were calculated as 30% of the total dried mass of green tea and about 50% ofthe catechins were considered as epigallocatechin gallate (EGCG). Results: A total of two types of nonprescription drugscontaining green tea powder or extracts, nine health functional food products, and three types of health foods were found. Theregulatory requirements of the EGCG exceeding 800 mg were reported to be associated with adverse effects of elevated liverenzyme. If consumers take several green tea products concurrently, such as nonprescription drugs with health functional foods orhealth foods, it could exceed the recommended amount of EGCG. Conclusion: The concurrent use of green tea products asnonprescription drugs, health functional foods, and healthy foods may lead to an increased exposure to EGCG. Pharmacists shouldbe aware the availability of various types of green tea products and the potential risk of liver toxicity due to excessive consumptionof EGCG.

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