Macro and Small over Micro: Macromolecules and Small Molecules that Regulate MicroRNAs

Kang, Soowon; Im, Kyungtaek; Baek, Jihae; Yoon, Sungroh; Min, Hyeyoung

doi:10.1002/cbic.201402007

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Macro and Small over Micro: Macromolecules and Small Molecules that Regulate MicroRNAs

Kang, Soowon;
Im, Kyungtaek;
Baek, Jihae;
Yoon, Sungroh;
Min, Hyeyoung

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8

초록

Given the correlation between the deregulation of specific miRNAs and disease onset, it is critical to identify miRNA regulators that effectively control miRNAs involved in the pathogenesis of target diseases. This review provides the latest update on oligonucleotide- and small-molecule-based miRNA regulators, and discusses assays developed to screen for small-molecule regulators. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

키워드

high-throughput screening; microRNAs; regulators; RNA; small molecules; BREAST-CANCER CELLS; ROLLING-CIRCLE AMPLIFICATION; CHRONIC LYMPHOCYTIC-LEUKEMIA; LOCKED NUCLEIC-ACID; DRUG DISCOVERY; GENE-EXPRESSION; ANTISENSE OLIGONUCLEOTIDES; RNA-INTERFERENCE; MAMMALIAN-CELLS; MIR-21 FUNCTION

제목: Macro and Small over Micro: Macromolecules and Small Molecules that Regulate MicroRNAs

저자: Kang, Soowon; Im, Kyungtaek; Baek, Jihae; Yoon, Sungroh; Min, Hyeyoung

DOI: 10.1002/cbic.201402007

발행일: 2014-05

유형: Review

저널명: ChemBioChem

권: 15

호: 8

페이지: 1071 ~ 1078