Aquilanols A and B, Macrocyclic Humulene-Type Sesquiterpenoids from the Agarwood of Aquilaria malaccensis

Ma, Chi Thanh; Eom, Taeyong; Cho, Eunji; Wu, Bo; Kim, Tae Ryong; Oh, Ki Bong; Han, Sang Beom; Kwon, Sung Won; Park, Jeong Hill

doi:10.1021/acs.jnatprod.7b00462

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Aquilanols A and B, Macrocyclic Humulene-Type Sesquiterpenoids from the Agarwood of Aquilaria malaccensis

Ma, Chi Thanh;
Eom, Taeyong;
Cho, Eunji;
Wu, Bo;
Kim, Tae Ryong;
... Han, Sang Beom;
외 3명

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WEB OF SCIENCE

39

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SCOPUS

43

초록

Four new and five known sesquiterpenoids were isolated from the agarwood of Aquilaria malaccensis. Aquilanols A and B (1 and 2) have an unprecedented macrocyclic humulene structure with a bicyclic 7/10 ring system. Compound 2 was obtained as a scalemic mixture that was resolved by HPLC analysis using a chiral column. Their structures were deduced based on spectroscopic data analysis, and the absolute configurations were unambiguously determined by X-ray crystallographic data and ECD spectroscopic analysis. A putative biosynthetic pathway of these sesquiterpenoids is proposed.

키워드

2-(2-PHENYLETHYL)CHROMONE DERIVATIVES; =2-(2-PHENYLETHYL)-4H-1-BENZOPYRAN-4-ONE DERIVATIVES; CHINESE

제목: Aquilanols A and B, Macrocyclic Humulene-Type Sesquiterpenoids from the Agarwood of Aquilaria malaccensis

저자: Ma, Chi Thanh; Eom, Taeyong; Cho, Eunji; Wu, Bo; Kim, Tae Ryong; Oh, Ki Bong; Han, Sang Beom; Kwon, Sung Won; Park, Jeong Hill

DOI: 10.1021/acs.jnatprod.7b00462

발행일: 2017-11

유형: Article

저널명: Journal of Natural Products

권: 80

호: 11

페이지: 3043 ~ 3048