Transcriptome profiling and genomic atlas study for endocrine disrupting chemicals in whole body system of animals

초록

Understanding the biological phenomena encoded through the genome is important. Therefore, it is possible to identify the genes of each organism and infer the characteristics and similarities of each other through the genomic analysis. RNA-seq is a representative method among methods for comparing gene expression levels through transcriptome analysis. It is accompanied by next generation sequencing (NGS) and enables highly quantitative and wide-range precise measurement. A representative research method that includes whole genome contents is to construct a biological map. Using the atlas, it is possible to conduct research that includes all comprehensive genetic information to identify specific locations where genes are expressed through gene location mapping. In addition, by identifying the correlation between the gene and the biomarker in the network, select a significant biomarker and functional analysis could be performed. Endocrine disruptors cause diseases by disrupting endocrine function in the body. Bisphenol A, a representative endocrine disruptor, is most permeated in daily life, threatening human health, obesity and spermatogenesis. This review focuses on transcriptome profiling and genomic atlas construction that can provide comprehensive biological insights in animal genetics studies and information of endocrine disrupting chemicals.

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