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Synthesis and Biological Evaluation of Decursin, Prantschimgin and Their Derivatives
- Xia, Yan;
- Min, Kyung Hoon;
- Lee, Kyeong
Citations
WEB OF SCIENCE
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11초록
The synthesis of coumarin-based natural products and their derivatives is described. In vitro MDR reversal activities of the synthesized compounds were evaluated in P-glycoprotein over-expressing human sarcoma cell line MES-SA/DX5. Some of the coumarin derivatives were found to show potent MDR reversal activity. In particular, pyridyl derivative (15e) exhibited more potency than verapamil.
키워드
Coumarins; Decursin; Prantschimgin; Multidrug resistance; P-glycoprotein; ANGELICA-GIGAS; MULTIDRUG-RESISTANCE; DRUG-RESISTANCE; CANCER; ANGELATE; MECHANISMS; COUMARINS; AGENT; CELLS; ROOT
- 제목
- Synthesis and Biological Evaluation of Decursin, Prantschimgin and Their Derivatives
- 저자
- Xia, Yan; Min, Kyung Hoon; Lee, Kyeong
- 발행일
- 2009-01
- 유형
- Article
- 권
- 30
- 호
- 1
- 페이지
- 43 ~ 48
- 언어
- ENG
- 출판사
- WILEY-V C H VERLAG GMBH
- 발행국가
- 대한민국
- 분량
- 6 페이지
- ISSN
- E 1229-5949
P 1229-5949