fibrin glue가 이식 피부의 접착 및 생착에 미치는 영향

초록

The ability of a skin graft to adhere initially to a wound a bed is dependent on the formation of a stable fibrin bond the elastin in the graft and the elastin in the bed. the Factors preventiong such adhesion most commonly include bleeding, infection, mechanical disturbances of the adhesive mechanism, i.e., motion. This study was conducted to evaluate the adhesive effect of fibrin glue in the full-thickness skin grafts at 3,5,30,120minute and 8 hours after gluing in mice and the effect of fibrin glue on the skin graft take at the 3,7,15post operative days in rabbits. The result were as follows; (1) Mechanical testing demostrated that the shear adhesive strength of non-fibrin gluing control group was found to be 2.84m²(SD=2.68) after 3minutes of fixation At, 5minutes, the adhesive strength was 9.78gm/㎠(SD=2.68) after 3minutes of fixation. At 5minutes, the adhesive strength was 9.78gm/㎠(SD=5.61);at 30minutes, 30.78gm/㎠(SD=5.42); at 2hours, 53.14gm/㎠(SD=11.50); and at 8 hours, 108.08gm/㎠(SD=15.78) and that the shear adhesive strength of fibrin glue applied group was found to be 17.50gm/㎠(SD=5.79) after 3minutes of of fixation(after gluing). AT 5minutes, the adhesive strength was 24.30gm/㎠(SD=3.57); at 30minutes, 105.48gm/㎠(SD=15.27); at 2hours, 167.54gm/㎠(SD=58.12); and at 8hours, 286.22gm/㎠(SD=28.27). These results in shear adhesive strength were a significantly different between the experimental and the control groups at early skin grafts adherence. (2) The histologic examination did not demonstrate significant difference in healing process when the fibrin glue applied group were compared with the control group. With the above results, fibrin glue improved in early graft adherence without interference of the take of graft.

키워드