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3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier
- Baik, Hye Jung;
- Oh, Nam Muk;
- Oh, Young Taik;
- Yoo, Na Young;
- Park, So Young;
- ... Oh, Kyung Taek;
- 외 2명
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21초록
Polysaccharidic nanogels were fabricated with bovine serum albumin (BSA) and a glycol chitosan (GCS) grafted with functional 3-diethylaminopropyl (DEAP) groups. These nanogels were investigated to evaulate their cellular uptake in HeLa cells and in vivo fate in nude mice tumor model. Unlike free BSA, GCS-g-DEAP/BSA nanogels improved cellular uptake of BSA. Furthermore, this system led to an enhanced blood circulation and a high accumulation of BSA in the tumor site. Our collective results strongly support that GCS-g-DEAP/BSA nanogel is a potential carrier system for high molecular weight proteins. (C) 2011 Elsevier B.V. All rights reserved.
키워드
Polysaccharidic nanogels; Glycol chitosan; Bovine serum albumin; Ph-sensitivity; DELIVERY; NANOPARTICLES; NANOGELS; CELLS
- 제목
- 3-Diethylaminopropyl-bearing glycol chitosan as a protein drug carrier
- 저자
- Baik, Hye Jung; Oh, Nam Muk; Oh, Young Taik; Yoo, Na Young; Park, So Young; Oh, Kyung Taek; Youn, Yu Seok; Lee, Eun Seong
- 발행일
- 2011-06
- 유형
- Article
- 권
- 84
- 호
- 2
- 페이지
- 585 ~ 590
- 언어
- ENG
- 출판사
- ELSEVIER SCIENCE BV
- 발행국가
- 네덜란드
- 분량
- 6 페이지
- ISSN
- E 1873-4367
P 0927-7765