TheGRIN2BandGRIN2AGene Variants Are Associated With Continuous Performance Test Variables in ADHD

초록

Objective:To examine the association between variants of N-methyl-D-aspartate (NMDA) receptor subunit-encoding genes (GRIN2AandGRIN2B) and continuous performance test (CPT) variables in ADHD and healthy controls.Method:In all, 253 ADHD patients and 98 controls were recruited. The diagnosis, genotype, and diagnosis-genotype interaction effects for the CPT variables were examined.Results:Significant diagnosis effects were detected for all CPT variables. There were significant genotype and interaction effects on response time variability (RTV) by theGRIN2Bvariant. The C/C subgroup had higher RTV than the C/T + T/T subgroup in ADHD, but not in controls. There were significant genotype effects on omission errors by theGRIN2Avariant. The G/G subgroup had more omission errors than the G/A + A/A subgroup in ADHD patients, but not in controls.Conclusion:These results suggest that the genetic variants ofGRIN2BandGRIN2Aconfer an increased susceptibility to attentional impairment in ADHD patients.

키워드