Symmetrical Peripheral Gangrene Caused by High Dose Vasopressors: Two Case Reports

초록

Vasopressors, such as norepinephrine, dopamine and vasopressin are commonly used treatments for the major circulatory failure. Despite of its favorable purpose, these agents induce adverse effects. Symmetrical peripheral gangrene (SPG) is a rare but severe complication characterized by ischemic changes of two or more extremities without larger vessel occlusion. Recently, we experienced 2 cases of SPG caused by vasopressor infusion that progressed in different courses. Both cases showed severe ischemic changes in every digit but only the second case aggravated to lower limb surface necrosis. Treatments should be based on the complication of each vasopressor and be individualized by each patient. Further studies concerning maximal dose of each vasopressor are required.

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