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The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo
- Kong, Sun-Young;
- Kim, Kwang-Soo;
- Kim, Jiewan;
- Kim, Min Kyeong;
- Lee, Ki Hong;
- ... Kim, Keun Pil;
- 외 8명
WEB OF SCIENCE
33SCOPUS
32초록
Triple-negative breast cancer is a highly aggressive tumor subtype that lacks effective therapeutic targets. Here, we show that ELK3 is overexpressed in a subset of breast cancers, in particular basal-like and normal-like/claudin-low cell lines. Suppression of ELK3 in MDA-MB-231 cells led to transdifferentiation from an invasive mesenchymal phenotype to a non-invasive epithelial phenotype both in vitro and in vivo. Suppression of ELK3 resulted in extensive changes in genome expression profiles. Among these, GATA3, a master suppressor of metastasis, was epigenetically activated. Also, suppression of GATA3 led to the restoration of migration and invasion. These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of MDA-MB-231 cells.
키워드
- 제목
- The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells in vitro and in vivo
- 저자
- Kong, Sun-Young; Kim, Kwang-Soo; Kim, Jiewan; Kim, Min Kyeong; Lee, Ki Hong; Lee, Je-Yong; Oh, Nuri; Park, Ji-In; Park, Ji-Hoon; Heo, Sun-Hee; Shim, Sung Han; Lee, Dong Ryul; Kim, Keun Pil; Park, Kyung-Soon
- 발행일
- 2016-10
- 유형
- Article
- 저널명
- Oncotarget
- 권
- 7
- 호
- 40
- 페이지
- 65137 ~ 65146
- 출판사
- IMPACT JOURNALS LLC
- 발행국가
- 미국
- 분량
- 10 페이지
- ISSN
- E 1949-2553
P 1949-2553