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Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice
- Jeong, Mi Sook;
- Choi, Sun Eun;
- Kim, Ji Young;
- Kim, Jung Shim;
- Kim, Eun Joo;
- ... Lee, Mi-Kyung;
- ... Li, Kap-Sok;
- ... Moon, Nam Ju;
- 외 8명
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27초록
Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.
키워드
ALNUS-JAPONICA STEUDEL; ATONIC DERMATITIS; NITRIC-OXIDE; NC MICE; DIARYLHEPTANOIDS; EXPRESSION; EXTRACT; ASTHMA; CELLS; BARKS
- 제목
- Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice
- 저자
- Jeong, Mi Sook; Choi, Sun Eun; Kim, Ji Young; Kim, Jung Shim; Kim, Eun Joo; Park, Kwan Hee; Lee, Do Ik; Joo, Seong Soo; Lee, Chung Soo; Bang, Hyoweon; Lee, Mi-Kyung; Choi, Young Wook; Li, Kap-Sok; Moon, Nam Ju; Lee, Min Won; Seo, Seong Jun
- 발행일
- 2010-12
- 유형
- Article
- 권
- 2010
- 언어
- ENG
- 출판사
- HINDAWI PUBLISHING CORPORATION
- 발행국가
- 미국
- ISSN
- E 1740-2530
P 1740-2522