사람 간암, 간경화, 간염 및 태아간에서 Alpha-Fetoprotein함유세포에 관한 면역조직화학적 연구

초록

The alpha-fetoprotein containing cells(AFP cells) were studied immunohistochemically in human primary hepatocellular carcinoma(HCC), liver cirrhosis(LC), chronic active hepatitis(CAH), chronic persistent hepatitis(CPH) and fetal liver. 1) Fetal Liver: AFP cells began to appear at 5 gestation weeks with localized granular immunostaining productions around perinuclear cytoplasm. With age, AFP cells appeared mainly around central vein and subcapsular area. After 14 gestation weeks, AFP cells were widely distributed throught tissue section with diffuse pattern. By 33 gestation weeks, intensity of immune response and frequency of AFP cells greatly decreased. 2) HCC: 8 cases of 11 HCC exhibited positive reaction and mainly perinuclear immunostaining production was observed. Neoplastic nodules composed of trabeculae in 4-5 cell layers resembled the developing fetal liver. The distribution and the frequency of AFP cells in neoplastic nodules were variable. The amount of immunostaining production in each AFP cell was inconstant but the intensity of immune stating was constant. AFP cells were present with increased frequency in the periphery of neoplastic trabeculae but this was not the case around the neoplastic connective tissue. 3) Liver Cirrhosis and Hepatitis: 2 cases among 12 cirrhosis exhibited very weak and diffuse positive reaction in the cytoplasm but no positive reaction was observed in 14 CAH and 3 CPH.

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