Recent advances in the copper-catalyzed aerobic Csp3-H oxidation strategy

초록

The interplay between copper catalysts and molecular oxygen provides the opportunity to control the promiscuous catalytic behaviors in aerobic C-sp(3)-H bond oxidations without using stoichiometric amounts of oxidants. This mini-review aims to cover the Cu-catalyzed aerobic benzylic and alpha-carbonyl C-sp(3)-H oxidations and that of the carbon next to an amine group in the past five years. The development of tandem multicomponent reactions employing aerobic C-sp(3)-H bond oxidations will be discussed to highlight the controlled catalyst behaviors and the catalyst interactions between multiple reaction components.

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