LC-MS/MS를 이용한 비글견 혈장 중 파록세틴의 고감도 분석

초록

A simple and sensitive method for the determination of paroxetine in canine plasma was developedand validated by liquid-liquid extraction and liquid chromatography-tandem mass spectrometry (LC-/MS/MS).Fluoxetine was used as an internal standard. Paroxetine and internal standard in plasma samples were extractedusing TBME (tert-butyl methyl ether). A centrifuged upper layer was then evaporated and reconstituted with. Corresponding authorPhone : +82-(0)2-3461-9133 Fax : +82-(0)2-3461-0590E-mail: hejolee0@yahoo.co.kr

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