Clinical factors affecting intraocular pressure change after orbital decompression surgery in thyroid-associated ophthalmopathy

초록

Objective: To report the physiological monitoring of intraocular pressure (10P) during the postoperative periods after orbital decompression surgery and ascertain the correlation between the clinical factors and loP changes. Methods: The medical records 4113 orbits from 60 patients who underwent orbital decompression were reviewed retrospectively. IOP measurement during the postoperative periods was classified based on the postoperative day: week 1 (1-7 days), month 1 (8-41 days), month 2 (42-70 days), month 3 (71-97 days), month 4 (98-126 days), and final (after 127 days). The mean postoperative follow-up was 286.5 days for orbits with at least 6 months of follow-up. Univariate and multivariate linear regression analyses were performed to assess the correlation between the IC)P reduction percentage and clinical factors. Results: The mean IOP increased from 16.9 to 18.6 nunHg (10.1%) at postoperative week 1 and decreased to 14.4 nunHg (14.5%) after 2 months. Minimal little changes were observed postoperatively in the 10P after 2 months. Preoperative 10P had a significant positive effect on the reduction percentage both at postoperative week 1 (beta=2.51, P=0.001) and after 2 months (beta=1.07, P=0.029), and the spherical equivalent showed a positive correlation with the reduction level at postoperative week 1 (beta=1.71, 1'=0.021). Conclusion: Surgical decompression caused a significant reduction in the 10P in thyroid associated orbitopathy, and the amount of reduction was closely related to preoperativre 10P; however, it may also cause a transient elevation in the IOP during the early postoperative phase in highly myopic eyes.

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