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초록
The Stewartia koreana Nakai (SK) had been used in oriental traditional medicine as a remedy for acute gastroenteritis, liver diseases, quadriplegia and pain. The antioxidant activity guided isolation 80% methyl extract from stems of SK yielded eight phenolic compounds. We evaluated the anti-oxidative and anti-inflammatory effects of these compounds via assays of 1,1-diphenyl-2-picrylhydazyl (DPPH) radicals and inhibition of nitric oxide (NO) production in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. The results demonstrated that syringaresinol (6) exhibited significant DPPH radical-scavenging activity and inhibitory effects on NO production compared with its positive controls, ascorbic acid and L-NMMA, respectively.
키워드
Stewartia koreana; antioxidants; radical scavengers; nitric oxide; NF-KAPPA-B; NITRIC-OXIDE; LIGNANS; CONSTITUENTS; FLAVONOIDS; ACTIVATION; CELLS
- 제목
- The comparison of DPPH-scavenging capacity and anti-inflammatory effects of phenolic compounds isolated from the stems of Stewartia koreana Nakai
- 저자
- Kim, Manh Heun; Jang, Jun Hye; Oh, Myeong Hwan; Heo, Jun Hyeok; Lee, Min Won
- 발행일
- 2014-09-02
- 유형
- Article
- 권
- 28
- 호
- 17
- 페이지
- 1409 ~ 1412