Recent advances in ph-or/and photo-responsive nanovehicles

Shin, Y.; Husni, P.; Kang, K.; Lee, D.; Lee, S.; Lee, E.; Youn, Y.; Oh, K.

doi:10.3390/pharmaceutics13050725

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Recent advances in ph-or/and photo-responsive nanovehicles

Shin, Y.;
Husni, P.;
Kang, K.;
Lee, D.;
Lee, S.;
... Oh, K.;
외 2명

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46

초록

The combination of nanotechnology and chemotherapy has resulted in more effective drug design via the development of nanomaterial-based drug delivery systems (DDSs) for tumor targeting. Stimulus-responsive DDSs in response to internal or external signals can offer precisely controlled delivery of preloaded therapeutics. Among the various DDSs, the photo-triggered system improves the efficacy and safety of treatment through spatiotemporal manipulation of light. Additionally, pH-induced delivery is one of the most widely studied strategies for targeting the acidic micro-environment of solid tumors. Accordingly, in this review, we discuss representative strategies for designing DDSs using light as an exogenous signal or pH as an endogenous trigger. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

키워드

Acid-labile bond; Chemotherapy; Light; Nanovehicles; PH; Photodynamic; Photothermal; Protonation; Stimuli; DRUG-DELIVERY SYSTEMS; MESOPOROUS SILICA NANOPARTICLES; CHEMO-PHOTOTHERMAL THERAPY; BLOCK-COPOLYMER MICELLES; FLOWER-LIKE MICELLES; PLGA-PEG-PLGA; PHOTODYNAMIC THERAPY; BIOMEDICAL APPLICATIONS; INTRACELLULAR DELIVERY; SENSITIVE MICELLES

제목: Recent advances in ph-or/and photo-responsive nanovehicles

저자: Shin, Y.; Husni, P.; Kang, K.; Lee, D.; Lee, S.; Lee, E.; Youn, Y.; Oh, K.

DOI: 10.3390/pharmaceutics13050725

발행일: 2021-05

유형: Article

저널명: Pharmaceutics

권: 13

호: 5