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Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B
- Han, Arim;
- Chae, Yun-Cheol;
- Park, Jin Woo;
- Kim, Kee-Beom;
- Kim, Ji-Young;
- ... Seo, Sang Beom
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12초록
Here we report that the H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. Negative regulation of ANGPT1 by KDM3B is independent of its Jumonji (JmjC) domain-mediated H3K9 demethylase activity. We demonstrate that KDM3B downregulates ANGPT1 via interaction with SMRT, and suggest that the repressor complex is formed at the promoter area of ANGPT1. Using MTT and wound healing assays, depletion of KDM3B was found to increase cell proliferation and cell motility, indicating that KDM3B has a role in angiogenesis.
키워드
ANGPT1; Cell motility; KDM3B; SMRT; Transcription; METHYLTRANSFERASE G9A; ANGIOPOIETIN-1; EXPRESSION; ANGIOGENESIS; COACTIVATOR; ENDOTHELIUM; ACTIVATION; LEUKEMIA; RECEPTOR
- 제목
- Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B
- 저자
- Han, Arim; Chae, Yun-Cheol; Park, Jin Woo; Kim, Kee-Beom; Kim, Ji-Young; Seo, Sang Beom
- 발행일
- 2015-07
- 유형
- Article
- 저널명
- BMB Reports
- 권
- 48
- 호
- 7
- 페이지
- 401 ~ 406
- 언어
- ENG
- 출판사
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- 발행국가
- 대한민국
- 분량
- 6 페이지
- ISSN
- E 1976-670X
P 1976-6696