Lipoic Acid Functionalized Silver Nanoprisms for Colorimetric Sensing of ?-Aminobutyric Acid, Selenite and Myoglobin

초록

Silver nanoprisms (AgNPRs) are synthesized by silver nitrate through chemical reduction method using sodium borohydride and hydrogen peroxide. AgNPRs were functionalized with lipoic acid (LA) and successfully integrated with UV-visible spectrophotometry for simultaneous detection of multiple biomarkers such as & gamma;-aminobutyric acid (GABA), selenite, and myoglobin. The as-prepared LA-AgNPRs exhibited surface plasmon resonance (SPR) characteristic peak at 660 nm. The SPR band of LA-AgNPRs was blue-shifted to 439, 390, and 479 nm upon the addition of GABA, selenite, and myoglobin, respectively. The limits of detection are 6.32, 0.35 and 20.40 nM for GABA, selenite, and myoglobin, respectively. The LA-AgNPRs sensor displays potential prospect to detect three biomarkers GABA, selenite, and myoglobin in biofluid samples. Lipoic acid was functionalized on the surfaces of silver nanoprisms for colorimetric sensing of GABA, selenite and myoglobin with different spectral characteristics. This method exhibited the detection limits of 6.32, 0.35 and 20.40 nM for GABA, selenite, and myoglobin, respectively. This method was successfully applied to quantify three three biomarkers GABA, selenite, and myoglobin in biofluids.image

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