IN VITRO ACTIVITY OF LOQUAT LEAF EXTRACT AGAINST OXIDATIVE DAMAGE IN NEURONAL CELL

초록

This study was conducted to investigate the in vitro neuroprotective and antioxidative activities of aqueous loquat extract (LLE). The loquat leaf extracts inhibited lipid peroxidation and showed protective effects against H2O2-induced neurotoxicity in a dose-dependent manner. In the neuronal cell (PC 12) viability assay, LLE showed a protective effect against H2O2-induced neurotoxicity, and the release of lactate dehydrogenase (LDH) into the medium was also inhibited (28.94-52.09%). The total phenolic content of LLE was 42.55 mg/gallic acid equivalent (GAE) g, and the major phenolic compounds were rutin, epicatechin, and catechin. These data suggest that an LLE that includes the above phenolics may be useful as a natural antioxidant substance.

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