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Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
- Lee, Yeong-Geun;
- Kang, Kyung Won;
- Hong, Woojae;
- Kim, Yeon Hwa;
- Oh, Jen Taek;
- ... Seo, Young-Jin;
- 외 6명
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26초록
Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.
키워드
Antiviral agents; Agrimonia pilosa; APRG64; COVID-19; Galla rhois; SARS-CoV-2; AGRIMONIA-PILOSA LEDEB.; GALLA-RHOIS; CONSTITUENTS; CORONAVIRUS; FLAVONOIDS; QUERCETIN
- 제목
- Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
- 저자
- Lee, Yeong-Geun; Kang, Kyung Won; Hong, Woojae; Kim, Yeon Hwa; Oh, Jen Taek; Park, Dae Won; Ko, Minsung; Bai, Yung-Feng; Seo, Young-Jin; Lee, Sang-Myeong; Kim, H.; Kang, S.C.
- 발행일
- 2021-09
- 유형
- Article
- 권
- 45
- 언어
- ENG
- 출판사
- Elsevier Ltd
- 발행국가
- 영국
- ISSN
- E 1464-3391
P 0968-0896