Influence of Water Soluble Polymers on Crystallization of 5-Guanosine Monophosphate

초록

In presence of a polymer, the crystallization of low MW organic materials can be stopped at an intermediary step, where mesocrystals can be identified. A mesocrystal is defined as a superstructure of nanoparticles having polymer-adsorbed crystal faces on the scale of several hundred nanometers to micrometers. This stady examined the effects of water soluble polymers and relevant parameters on the formation of guanosine-5-monophosphate mesocrystals, it was observed OM and SEM that GMP obtained in a polymer solution had a unique particle morphology, different from the typical one of GMP. XRD analysis indicated that the polymer-directed crystallized GMP had a difference polymorph of GMP. This result shows that the crystal structure of GMP can be changed by polymers. It was observed in TGA analysis that the polymer-directed crystallized GMP had a different water content increasing a different type of hydrate.

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