The improvement of learning and memory ability of normal persons by BF-7

Citations

SCOPUS

9

초록

To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.

키워드

Acetylcholine; BF-7; Brain; Learning and memory; Neuroprotection; acetylcholine; bf 7; natural product; placebo; tissue extract; unclassified drug; acetylcholine brain level; adolescent; animal experiment; animal model; animal tissue; article; brain function; cholinergic nerve cell; clinical trial; controlled clinical trial; controlled study; dose response; drug mechanism; human; human experiment; learning; male; memory; neuroprotection; nonhuman; normal human; rat; silkworm
제목
The improvement of learning and memory ability of normal persons by BF-7
저자
Lee, Sang Hyung; Kim, Yong Sik; Kang, Yong Koo; Kwon, Oh Sang; Shin, Yong Kyoo; Song, Jin Ho; Lee, Moo Yeol; Lee, Kwang-Gil; Yeo, Joo-Hong; Lee, Won Bok; Lee, Tae Jin; Kim, Sung Su
발행일
2004-12
유형
Article
저널명
The Korean Journal of Physiology & Pharmacology
권
8
호
6
페이지
307 ~ 312