태아 26예에서 신장단위의 미세구조적 발달

초록

The differentiation process of renal corpuscles and tubules was studied ultrastructurally with 26 human fetal kidneys. The results obtained were as follows. 1. Renal vesicle was composed of stratified or pseudostratified columnar epithelium, the nuclei of which were displaced to the periphery of vesicle. The lumen to be formed was firstly filled with the cytoplasms between which intercellular junctions were present even with opposing cells. 2. Comma shaped body and S-shaped body were composed of pseudostratified or simple columnar epithelium and the cells at the cleft were elongated. With the differentiation of visceral cells into podocytes, glomerular basement membrane was formed actively on visceral cells, but not on capillary endothelium. 3. The zonular occludens was displaced from luminal side to glomerular basement membrane, and the two glomerular basement membranes along with both podocytes and endothelial cells were fused with the narrowing of space between the cells to form single layer consisted of central lamina densa and lamina raras on both sides. 4. With differentiation, the thick capillary wall of endothelium became thin by large cisterns in the cytoplasms which disappeared in developed endothelium. 5. Microvilli and vacuolar structures were more easily observed in proximal tubule than in distal tubule.

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