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Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens
- Lee, Dong Gu;
- Mok, So-Youn;
- Choi, Changsun;
- Cho, Eun Ju;
- Kim,Hyun Young;
- ... Lee, Sanghyun
초록
To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC50 value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.
키워드
Blumea balsamifera; Apigenin; Aldose Reductase Inhibition; HPLC
- 제목
- Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens
- 저자
- Lee, Dong Gu; Mok, So-Youn; Choi, Changsun; Cho, Eun Ju; Kim,Hyun Young; Lee, Sanghyun
- 발행일
- 2012-11
- 저널명
- Journal of Agricultural Chemistry and Environment
- 권
- 1
- 호
- 1
- 페이지
- 28 ~ 33
- 분량
- 6 페이지
- ISSN
- E 2325-744X
P 2325-7458