Antihepatotoxic effect of ethanol extracts from steam-dried ginseng berry on D-galactosamine/lipopolysaccharide-sensitized mice

Jang, S.K.; Park, J.S.; Ahn, J.W.; Jo, B.; Kim, H.S.; Kim, J.; Kim, S.Y.; Park, J.Y.; Lee, D.I.; Park, H.Y.; Joo, S.S.

doi:10.9721/KJFST.2017.49.6.676

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Antihepatotoxic effect of ethanol extracts from steam-dried ginseng berry on D-galactosamine/lipopolysaccharide-sensitized mice

Jang, S.K.;
Park, J.S.;
Ahn, J.W.;
Jo, B.;
Kim, H.S.;
외 6명

Citations

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2

초록

The present study aimed to examine the hepatoprotective effects of ethanol extracts from steam-dried ginseng berry (SGBE) in both D-Galactosamine/Lipopolysaccharide (D-GalN/LPS)-sensitized mice and in vitro models. Our results clearly demonstrated that SGBE significantly reduced the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase in blood, and TNFα was normalized in 8 h after the treatment with D-GalN/LPS. Coincidently, major organs remained unimpaired when compared to D-GalN/LPS control group. Moreover, p38, which stimulates expression of NAFLD-associated cytokines, was markedly inhibited when treated with SGBE. In vitro analysis revealed that the main components of SGBE, linoleic acid and ginsenoside Re/Rd, may play a role in protecting liver from D-GalN/LPS-induced toxicity. Finally, we concluded that SGBE may be a promising therapeutic agent for preventing damage to the liver. © The Korean Society of Food Science and Technology.

키워드

D-galactosamine/lipopolysaccharide; Ginseng berry; Ginsenoside; Linoleic acid; Non-alcoholic fatty liver disease

제목: Antihepatotoxic effect of ethanol extracts from steam-dried ginseng berry on D-galactosamine/lipopolysaccharide-sensitized mice

저자: Jang, S.K.; Park, J.S.; Ahn, J.W.; Jo, B.; Kim, H.S.; Kim, J.; Kim, S.Y.; Park, J.Y.; Lee, D.I.; Park, H.Y.; Joo, S.S.

DOI: 10.9721/KJFST.2017.49.6.676

발행일: 2017-12

유형: Article

저널명: 한국식품과학회지

권: 49

호: 6

페이지: 676 ~ 684