백서 족부에 산성 식염수 반복 주사로 기계적 통각과민 유발

초록

Background: The purpose of this study was to characterize an animal model of persistent mechanical hyperalgesia induced by repeated intraplantar injection of low pH saline. Methods: Saline, at pHs of 4, 5, 7 and 7.4, was intraplantarily injected into the hind paw twice, 5 days apart. To quantify the hyperalgesia, the withdrawal threshold (WT) to mechanical stimuli was measured on the following schedule: before the first injection; 2 h and 4 h after the first injection; before the second injection and 4 h and weekly (6 weeks) after the second injection. The paw withdrawal latency to radiant heat was also measured with pH 4 saline. Mechanical hyperalgesia (MH) due to an intraplantar, subcutaneous injection was compared with that of a gastrocnemius muscle injection at pH 4. Results: Two unilateral injections of pH 4 and 5 saline solutions caused bilateral mechanical, but not heat hyperalgesia, which lasted 3-4 weeks. An intraplantar injection of pH 4 saline showed a higher WT than the gastrocnemius muscle injection 4 hours after the second injection, but there was no significant difference between the two. Conclusions: Repeated intraplantar injections of low pH saline produced bilateral long-lasting MH in rats, but there was no significant difference in the WT between muscle and subcutaneous injections.

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