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The Palladium-Catalyzed Trifluoromethylation of Vinyl Sulfonates
- Cho, Eun Jin;
- Buchwald, Stephen L.
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151초록
A method for the palladium-catalyzed trifluoromethylation of cyclohexenyl sulfonates has been developed. Various cyclohexenyl triflates and nonaflates underwent trifluoromethylation under mild reaction conditions using a catalyst system composed of Pd(dba)(2) or [(ally1)PdCl](2) and the monodentate biaryl phosphine ligand (t)BuXPhos. The trifluoromethyl anion (CF3-) or its equivalent for the process was generated in situ from TMSCF3 in combination with KF or TESCF3 in combination with RbF.
키워드
OXIDATIVE TRIFLUOROMETHYLATION; MEDICINAL CHEMISTRY; BORONIC ACIDS; ESTER ENOLATE; FLUORINE; PANOMIFENE; ARYL; PERFLUOROALKYLATION; REAGENTS; AGENTS
- 제목
- The Palladium-Catalyzed Trifluoromethylation of Vinyl Sulfonates
- 저자
- Cho, Eun Jin; Buchwald, Stephen L.
- 발행일
- 2011-12
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 13
- 호
- 24
- 페이지
- 6552 ~ 6555
- 언어
- ENG
- 출판사
- AMER CHEMICAL SOC
- 발행국가
- 미국
- 분량
- 4 페이지
- ISSN
- E 1523-7052
P 1523-7060