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The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth
- Kim, Jeongkyu;
- Oberdoerffer, Philipp;
- Khurana, Simran
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11초록
The macroH2A1.2 histone variant facilitates the response to replication stress with implications for genome maintenance and cell growth. A mutually exclusive splice variant, macroH2A1.1, has opposing effects on DNA repair outcome and proliferation. Here we discuss the potential impact of splicing-modulated macroH2A1 chromatin organization for cell function and malignant transformation.
키워드
REPLICATION STRESS; CHROMATIN; CANCER; ROLES
- 제목
- The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth
- 저자
- Kim, Jeongkyu; Oberdoerffer, Philipp; Khurana, Simran
- 발행일
- 2018-06
- 유형
- Article
- 저널명
- MOLECULAR & CELLULAR ONCOLOGY
- 권
- 5
- 호
- 3
- 언어
- ENG
- 출판사
- TAYLOR & FRANCIS INC
- 발행국가
- 미국
- ISSN
- E 2372-3548
P 2372-3556