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Amide Acetal in Palladium-Catalyzed Allylation with Allylic Alcohols under Neutral Conditions
- Kwon, Yongseok;
- Jung, Jaehyun;
- Kim, Jae Hyun;
- Kim, Woo-Jung;
- Kim, Sanghee
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8초록
A mild and efficient palladium-catalyzed allylation reaction with allylic alcohols is described. The in situ activation of the allylic alcohol is achieved by using N,N-dimethylacetamide dimethyl acetal and a simple palladium catalyst (i.e., Pd(PPh3)(4)). The reaction system does not require acid or base additives or specially designed ligands. In addition to carbon nucleophiles, nitrogen and oxygen nucleophiles can also be used with the allylic alcohol in this transformation.
키워드
alcohols; allylation; amines; palladium; synthetic methods; BAYLIS-HILLMAN ADDUCTS; DIRECT AMINATION; SYNTHETIC REACTIONS; N-HETEROCYCLES; C-O; ALKYLATION; ACID; AMINES; SUBSTITUTION; EFFICIENT
- 제목
- Amide Acetal in Palladium-Catalyzed Allylation with Allylic Alcohols under Neutral Conditions
- 저자
- Kwon, Yongseok; Jung, Jaehyun; Kim, Jae Hyun; Kim, Woo-Jung; Kim, Sanghee
- 발행일
- 2017-05
- 유형
- Article
- 권
- 6
- 호
- 5
- 페이지
- 520 ~ 526