상세 보기
Intranasal Vaccination with Outer-Membrane Protein of <i>Orientia tsutsugamushi</i> induces Protective Immunity Against Scrub Typhus
- Park, Sung-Moo;
- Gu, Min Jeong;
- Ju, Young-Jun;
- Cheon, In Su;
- Hwang, Kyu-Jam;
- ... Son, Young Min;
- 외 8명
WEB OF SCIENCE
7SCOPUS
8초록
Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of O. tsutsugamushi (OMPOT) would induce a protective immunity against O. tsutsugamushi infection. It was particular interest that when mice were infected with O. tsutsugamushi, the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti- O. tsutsugamushi IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against O. tsutsugamushi. The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with O. tsutsugamushi infection causing subsequent pneumonia.
키워드
- 제목
- Intranasal Vaccination with Outer-Membrane Protein of <i>Orientia tsutsugamushi</i> induces Protective Immunity Against Scrub Typhus
- 저자
- Park, Sung-Moo; Gu, Min Jeong; Ju, Young-Jun; Cheon, In Su; Hwang, Kyu-Jam; Gill, Byoungchul; Shim, Byoung-Shik; Jeong, Hang-Jin; Son, Young Min; Choi, Sangho; Jeung, Woonhee; Han, Seung Hyun; Chu, Hyuk; Yun, Cheol-Heui
- 발행일
- 2021-04
- 유형
- Article
- 저널명
- Immune Network
- 권
- 21
- 호
- 2
- 언어
- ENG
- 출판사
- KOREA ASSOC IMMUNOLOGISTS
- 발행국가
- 대한민국
- ISSN
- E 2092-6685
P 1598-2629