Effects of brain-derived neurotrophic factor-catecholamine-O-methyltransferase gene interaction on schizophrenic symptoms

초록

The methionine variant of Va166Met brain-derived neurotrophic factor (BDNFmet) and catecholamine-O-methyltransferase (COMTL) is associated with a deficit in attention and aggravation of delusions in schizophrenia. We hypothesized that the BDNF-COMT gene interaction would affect the symptoms and cognition in schizophrenia. Ninety-six schizophrenic patients and 79 control participants were recruited. The patients who were BDNFmet/met x COMTL carriers had the highest scores of delusion of Positive Symptoms and the Scale for Assessment of Negative Symptoms, word reading of the color word test, and trail-making test B time, compared with the other three genotype interactions. The current results suggest that patients with the BDNFmet/met x COMTL allele had more delusional symptoms and poorer cognitive flexibility, compared with the other three genotype interactions. NeuroReport 19:1155-1158 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

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