Ultrasensitive and rapid detection of anthrax marker with a sers-based solenoid microfluidic sensor

Jeon, Jinhyeok; Chen, Hao; Gao, Rongke; Choo, Jaebum

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Ultrasensitive and rapid detection of anthrax marker with a sers-based solenoid microfluidic sensor

Jeon, Jinhyeok;
Chen, Hao;
Gao, Rongke;
Choo, Jaebum

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초록

We report a fully automated surface-enhanced Raman scattering (SERS)-based solenoid-embedded microfluidic device for the quantitative and sensitive detection of anthrax biomarker poly-γ-d-glutamic acid (PGA) in solution. Analysis is based on the competitive reaction between PGA molecules and PGAconjugated gold nanoparticles with anti-PGA-immobilized magnetic beads within a microfluidic environment. Magnetic immunocomplexes are trapped by solenoids embedded within the device, and their SERS signals were directly measured and analyzed. The limit of detection (LOD) of PGA in serum is estimated to be 100 pg/mL. We believe that the defined method represents a valuable analytical tool for the detection of anthrax-related aqueous samples. © 15CBMS-0001.

키워드

Anthrax; Microfluidics; Surface-enhanced Raman Scattering; Amino acids; Biomarkers; Diseases; Nanomagnetics; Raman scattering; Solenoids; Surface scattering; Anthrax; Competitive reactions; Limit of detection; Micro-fluidic devices; Micro-fluidic sensors; Microfluidic environment; Sensitive detection; Surface enhanced Raman Scattering (SERS); Microfluidics

제목: Ultrasensitive and rapid detection of anthrax marker with a sers-based solenoid microfluidic sensor

저자: Jeon, Jinhyeok; Chen, Hao; Gao, Rongke; Choo, Jaebum

발행일: 2015-10

유형: Conference Paper

저널명: MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

페이지: 1151 ~ 1153

언어: ENG

출판사: Chemical and Biological Microsystems Society

분량: 3 페이지

ISSN: P 0000-0000