유방암에서 DNA Topoisomerase II-α와 E2F-1의 면역조직화학적 발현과 임상 및 병리학적 연관성

초록

Purpose: Clinical courses of breast cancer are very different, and concern for finding a predictable marker of breast carcinomas has increased. This study focused on the relationship between the expressions of DNA topoisomerase II-α as a proliferative marker, and E2F-1 as a transcription factor, with clinicopathological factors of infiltrating duct carcinomas of the breast. Methods: We investigated the expressions of E2F-1 and DNA topoisomerase II-α in 43 patients with infiltrating ductal carcinomas using immunohistochemical staining, and the results were analyzed with regard to clinicopathological parameters. Results: Among 43 infiltrating ductal carcinomas, 24 (55.8%) were immunohistochemically negative on E2F-1 and 19 (44.2%) were positive. The expression of E2F-1 correlated with increased tumor size, positive axillary lymph node metastasis and high stage. The topoisomerase II-α index correlated with increased tumor size, positive lymph node metastasis, high stage, high histological grade and negative estrogen receptor. The expression of E2F-1 and the topo II-α index were significantly correlated. Conclusion: These results suggest that the expressions of DNA topoisomerase II-α and E2F-1 play some role as prognostic factors for infiltrating duct carcinomas of the breast, but much more study will be required. (J Korean Surg Soc 2003;64:93-100)

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