상세 보기
- Khunmanee, Sureerat;
- Choi, Anseo;
- Ahn, Il Young;
- Kim, Woo Ju;
- Bae, Tae Hui;
- ... Kang, Shin Hyuk;
- ... Park, Hansoo
WEB OF SCIENCE
11SCOPUS
7초록
Current trends in wound care research focus on creating dressings for diverse wound types, aiming to effectively control the wound healing process. We proposed a wound dressing composed of oxidized hyaluronic acid and amine gelatin with embedded lysine-modified gelatin nanoparticles (HGel-GNPs-lysine). This dressing improves mechanical properties and reduces degradation rates. The storage modulus for HGel-GNPs-lysine was 3,800 Pa, exceeding that of HGel (1,750 Pa). The positively charged surface of GNPs-lysine effectively eliminated Escherichia coli and Staphylococcus aureus. In a diabetic mice model (C57BL/6), HGel-GNPs-lysine immobilized with basic-fibroblast growth factor promoted granulation tissue thickness and collagen density. Gene expression analysis indicated that HGel-GNPs-lysine reduced inflammation and enhanced angiogenesis. This study highlights that HGel-GNPs-lysine could offer alternative treatment strategies for regulating the inflammatory response at the injury site in wound dressing applications. © 2024
키워드
- 제목
- Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel
- 저자
- Khunmanee, Sureerat; Choi, Anseo; Ahn, Il Young; Kim, Woo Ju; Bae, Tae Hui; Kang, Shin Hyuk; Park, Hansoo
- 발행일
- 2024-02
- 유형
- Article
- 저널명
- iScience
- 권
- 27
- 호
- 2